2003: Best International Actress
...for "Frida"
Golden Camera, Germany

2003: Best Actress - Film
...for "Frida"
Imagen Foundation Awards

2003: Special Silver Goddess
...for "Frida"
Mexican Cinema Journalists

2002: Outstanding Actor/Actress in a Made for Television Movie or Miniseries
...for "In the Time of the Butterflies"
ALMA Awards

2000: Favorite Supporting Actress - Action
...for "Wild Wild West"
Blockbuster Entertainment Awards

1998: Best Actress in Film
...for "Sistole Diastole"
Nosotros Golden Eagle Awards

2007: Outstanding Comedy Series (as executive producer)
...for "Ugly Betty"
Primetime Emmy Awards

2004: Outstanding Children/Youth/Family Special (as director)
...for "The Maldonado Miracle"
Daytime Emmy Awards

2003: Best Actress in a Leading Role
...for "Frida"
Academy Awards

2003: Best Performance by an Actress in a Leading Role
...for "Frida"
BAFTA Awards

2003: Best Actress
...for "Frida"
Broadcast Film Critics Association Awards

2003: Best Actress
...for "Frida"
Chicago Film Critics Association Awards

2003: Best Performance by an Actress in a Motion Picture - Drama
...for "Frida"
Golden Globes

2003: Best Performance by an Actress in a Motion Picture - Drama
...for "Frida"
Satellite Awards

2003: Outstanding Performance by a Female Actor in a Leading Role
...for "Frida"
Screen Actors Guild Awards

2002: Best Actress in a Picture Made for Television
...for "In the Time of the Butterflies"
Broadcast Film Critics Association Awards

2002: Best Mexican Working in a Foreign Movie
...for "Hotel"
MTV Movie Awards, Latin America

2002: Hottest Girl
...for "Y Tu Mamá También"
MTV Movie Awards, Latin America

2000: Outstanding Actress in a Feature Film
...for "Wild Wild West"
ALMA Awards

2000: Worst Supporting Actress
...for "Dogma" and "Wild Wild West"
Razzie Awards

1999: Outstanding Actress in a Feature Film
...for "54"
ALMA Awards

1998: Outstanding Actress in a Feature Film
...for "Fools Rush In"
ALMA Awards

1998: Outstanding Individual Performance in a TV Movie or Mini-Series
...for "The Hunchback"
ALMA Awards

1996: Best Supporting Actress
...for "Desperado"
Academy of Science Fiction, Fantasy & Horror Films

1996: Best Kiss (shared with Antonio Banderas)
...for "Desperado"
MTV Movie Awards

1995: Best Actress
...for "El Callejón de los milagros"
Ariel Awards